Cephalexin: Essential Guide to This Common Antibiotic

When working with Cephalexin, a first‑generation cephalosporin antibiotic used for a range of bacterial infections. Also known as Keflex, it targets gram‑positive bacteria and some gram‑negative strains., you’re dealing with a drug that belongs to the larger class of antibiotics, medicines that kill or stop growth of bacteria. These agents are essential for treating bacterial skin infections, conditions like cellulitis, impetigo, and wound infections caused by susceptible microbes. Because Cephalexin is a penicillin‑derived cephalosporin, it shares a beta‑lactam ring structure with penicillins, clinicians often consider cross‑allergy risk. Cephalexin is praised for its oral availability and relatively low side‑effect profile.

Dosage, Adjustments, and Resistance

Cephalexin encompasses treatment of many infections, but the exact dose hinges on the infection type, patient weight, and kidney function. Standard adult dosing ranges from 250 mg to 1 g every 6‑12 hours, while children receive weight‑based calculations. If a patient has renal impairment, the drug requires dosage reduction to avoid accumulation—a crucial adjustment that highlights the triple: Cephalexin requires dosage adjustment in renal impairment. Moreover, antibiotics influence bacterial resistance patterns; widespread use of Cephalexin without proper indication can foster resistant strains, especially methicillin‑resistant Staphylococcus aureus (MRSA). To minimize this risk, physicians follow stewardship guidelines, restricting use to infections proven or highly likely to respond. The drug’s safety profile includes common side effects like gastrointestinal upset, rash, and, rarely, Clostridioides difficile colitis. Understanding these nuances helps patients and providers balance effectiveness with safety.

Beyond simple dosing, Cephalexin’s role expands to special populations. Pregnant or breastfeeding individuals generally tolerate it well, but a healthcare professional should confirm the benefit outweighs any theoretical risk. For those allergic to penicillin, cross‑reactivity is possible but not guaranteed; skin testing can clarify the safest path. The drug also interacts with certain diuretics and anticoagulants, so a thorough medication review is essential before starting therapy. By recognizing how Cephalexin fits within the broader antibiotic landscape, you can make informed choices about when to use it, how to monitor response, and what signs warrant a medical review. Below you’ll find a curated set of articles that dive deeper into comparison guides, dosing tips, safety checks, and more, giving you the detailed knowledge you need to manage your health confidently.

Keftab (Cephalexin) vs Other Antibiotics: Pros, Cons & Alternatives

Keftab (Cephalexin) vs Other Antibiotics: Pros, Cons & Alternatives

A detailed comparison of Keftab (Cephalexin) with common antibiotic alternatives, covering how it works, pros, cons, dosing, safety, and when to choose other options.

Ruaridh Wood 17.10.2025