When you take piroxicam, a nonsteroidal anti-inflammatory drug (NSAID) used for pain and inflammation, often prescribed for arthritis or acute injuries. Also known as Feldene, it works by blocking enzymes that cause swelling and pain—but that same mechanism can also trigger serious side effects in many people. Unlike some other painkillers, piroxicam stays in your system longer, which means its effects last, but so do its risks.
One of the biggest concerns with piroxicam is damage to your stomach and intestines. It doesn’t just cause mild upset—it can lead to ulcers, bleeding, or even perforation, especially if you’re over 60, take it for more than a few days, or use it with blood thinners or steroids. You might not feel anything until it’s too late. If you notice black, tarry stools, vomiting blood, or sudden severe belly pain, stop taking it and get help right away. This isn’t rare—studies show up to 1 in 12 long-term users develop serious gastrointestinal problems.
NSAID side effects don’t stop at the gut. Piroxicam can raise your blood pressure, hurt your kidneys, and increase your chance of heart attack or stroke, even in people without prior heart issues. It’s not safe for everyone. If you have kidney disease, heart failure, or a history of ulcers, your doctor should avoid it or use extreme caution. Even if you’re young and healthy, using it for more than 10 days without a break increases your risk. Many people don’t realize that over-the-counter pain relievers like ibuprofen are safer for short-term use—piroxicam is meant for specific, chronic conditions under medical supervision.
Another hidden risk is skin reactions. Some users develop rashes, blisters, or peeling skin, especially if they’re exposed to sunlight. This isn’t just a sunburn—it’s a phototoxic reaction where the drug makes your skin hypersensitive. If your skin turns red, burns, or peels after minimal sun exposure, talk to your doctor. It’s not something you should ignore.
What you won’t find on the label? The fact that piroxicam can interact with common meds like antidepressants, diuretics, and even some herbal supplements. It can make your blood pressure meds less effective or cause lithium levels to spike dangerously. If you’re on multiple medications, you need to check for interactions before starting.
There’s no one-size-fits-all answer. Some people take piroxicam for months with no issues. Others have a bad reaction after one dose. The key is knowing your own body and watching for early signs. Keep a symptom journal—note any new stomach pain, swelling in your ankles, unusual fatigue, or skin changes. That info helps your doctor decide if the benefits outweigh the risks.
Below, you’ll find real, detailed guides from people who’ve dealt with piroxicam side effects, alternatives that work just as well without the danger, and practical tips to stay safe if you’re already on it. No fluff. Just facts you can use.
Piroxicam is an NSAID used for arthritis pain, offering long-lasting relief with once-daily dosing. But it carries serious risks like stomach bleeding and heart problems. Learn how it works, who should use it, and safer alternatives.
